|
Post by martin006 on Jun 11, 2019 2:22:12 GMT -5
Please post any information regarding Noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester).
Noopept is a Piracetam analogue with vastly increased potency (1000x, Ostrovskaya et al., 2002). As with piracetam, it acts as an allosteric AMPAR agonist, while also suppressing Ca2+-gated K+ channels as well as voltage-gated Ca2+ and K+ currents (Solnsteva et al., 1997).
It has been shown to have significant neuroprotective properties, as well as memory-enhancement in a number of animals models (Ostrovskaya et al., 1999, 2007, 2008; Pelsman et al., 2003). It also enhances activity of the immune system in both healthy and immune-compromised animals (Kovalenko et al., 2007).
It is prescribed in Russia and certain other eastern-european countries, though not in America.
It also readily crosse the blood-brain-barrier following oral administration in modest doses, though some people claim it has higher bioavailabilty sublingually and is ineffective orally (I can find no evidence for this, aside from anecdotal reports).
|
|
|
Post by twizzy on Jun 11, 2019 9:42:17 GMT -5
My basic experiments with Noopept nootropicboost.com/buy-best-nootropics/ have yielded the following - Noopept is highly soluble in water and glycerin (approximately 1:1) - There are no data to suggest that Noopept is more bioavailable via sublingual administration - No side-effects have been noted at 2x daily dosages of 20mg (PO) for 5 consecutive days, co-administered with 250mg CDP-choline (PO) per dose - In addition to the expected effects as a potent -racetam analogue, Noopept appears to have a minor stimulatory effect (non-physical) in regards to motivation, more marked than piracetam, aniracetam, oxiracetam or pramiracetam (akin to phenylpiracetam) - Most marked effects: increased focus, linguistic ease, enhanced semantic recall, reduced cognitive fatigue, enhanced abstract problem-solving capacity
|
|